Carbachol - induced long - term synaptic depression is enhanced during senescence at 2 hippocampal CA 3 - CA 1 synapses 3 4
نویسنده
چکیده
1 Carbachol-induced long-term synaptic depression is enhanced during senescence at 2 hippocampal CA3-CA1 synapses 3 4 5 6 7 Ashok Kumar 8 Department of Neuroscience, McKnight Brain Institute, University of Florida, 9 Gainesville, FL 32610 10 11 12 13 Total number pages: 34 14 Number of figures: 7 15 Number of tables: 0 16 Word in the abstract: 167 17 Word in the introduction: 609 18 Word in the discussion: 959 19 20 21 Running title: Carbachol induced synaptic depression during aging 22 23 24 25 26 27 Corresponding Author: 28 Ashok Kumar, Ph.D. 29 Department of Neuroscience, McKnight Brain Institute 30 University of Florida 31 PO Box 100244 32 Gainesville, FL 32610-0244, USA. 33 Phone (352) 392-4085 34 Fax (352) 392-8347 35 [email protected] 36
منابع مشابه
Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses.
Dysregulation of the cholinergic transmitter system is a hallmark of Alzheimer's disease and contributes to an age-associated decline in memory performance. The current study examined the influence of carbachol, a cholinergic receptor agonist, on synaptic transmission over the course of aging. Extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synapses in acute hi...
متن کاملEnduring Medial Perforant Path Short-Term Synaptic Depression at High Pressure
The high pressure neurological syndrome develops during deep-diving (>1.1 MPa) involving impairment of cognitive functions, alteration of synaptic transmission and increased excitability in cortico-hippocampal areas. The medial perforant path (MPP), connecting entorhinal cortex with the hippocampal formation, displays synaptic frequency-dependent-depression (FDD) under normal conditions. Synapt...
متن کاملLong-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield
Antidepressant drugs are usually administered for several weeks for the treatment of major depressive disorder. However, they are also prescribed in several additional psychiatric conditions as well as during long-term maintenance treatments. Antidepressants induce adaptive changes in several forebrain structures which include modifications at glutamatergic synapses. We recently found that repe...
متن کاملPostsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.
Activation of metabotropic glutamate receptors (mGluRs) with the group I mGluR selective agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) induces a long-term depression (LTD) of excitatory synaptic transmission in the CA1 region of the hippocampus. Here we investigated the potential roles of pre- and postsynaptic processes in the DHPG-induced LTD at excitatory synapses onto hippocampal pyramidal...
متن کاملIncreased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.
Evidence suggests that the long-term adaptations in the hippocampus after repeated drug treatment may parallel its role during memory formation. The neuroplasticity that subserves learning and memory is also believed to underlie addictive processes. We have reported previously that repeated morphine administration alters local distribution of endocytic proteins at hippocampal synapses, which co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010